Ford released the 10r80 in 2017 in select vehicles with the 3.5 ecoboost, similar to how ford released the 6.0 powerstroke as an option in 2004 along side the 7.3. in 2018 ford released the 10r80 as a standard option in f150's, expeditions, rangers, lincoln navigators and mustangs with different variations also released as the 10r60. its important to note that the 5.0 and 3.5/2.7/2.0 ecoboost versions of the 10r80/60 are not compatible due to bellhousing pattern differences.
The 10r80 comes with a fixed output shaft yoke that is designed to bolt to a 4 bolt flange on the driveshaft. What does this mean for ford swaps? generally older vehicles used slip yokes in the output with longer output shaft splines to allow the driveshaft to move in and out of the transmission, however the 10r80 has no provisions (from the factory) for a slip yoke as this was built into the 2-piece driveshaft (as seen in pictures below) the upper driveshaft comes from a mustang while the lower picture is the output of an f150 transmission both use similar connections however.
This means that all 10r80 transmissions will require a driveshaft with a built in slip-yoke rather than the typical slip-yoke built into the tailshaft of the transmission. This is because ford integrated the typical output shaft housing into the transmission case and made it non-removable. There is a possiblity of 4wd cases being modified to accept a slip yoke, but that is still to be seen. This is not a major stumbling point for 10r80 swaps, but must be taken into consideration due to not only the budgetary impacts (most custom driveshafts with integrated slip yoke are 1200+$) but also physical limitations as the driveshaft must be atleast long enough to allow integration of the slip yoke, so very short wheelbase vehicle swaps may run into issues.
The ford 10r80 also has differences internally on the valve body specifically with the "clutch apply valve" being added where as the gm valve body omitted this feature. Its interesting to note however that while GM decided ultimately to not use this valve it has been reported to have been found on GM units with the entrance holes blocked off in the separator plate. Ford also uses a different transmission filter.